Vancoced
BRAND NAMEVancoced
COMPOSITON Sterile Vancomycin Hydrochloride 0.5/1G Vials
SALT INFORMATIONVancomycin
TYPICAL USAGE

Used as empirical therapy in patient of Cellulitis, ICU Sepsis, Endocarditis, Bacterial Meningitis, Hospital Acquired Pneumonia, Post Surgical Wound infection, Bone & Joint infection, Vascular catheter Infections.

SIDE EFFECTS ------------------------
DRUG INTERACTION---------------------
MECHANISM OF ACTION

The bactericidal action of vancomycin results primarily from inhibition of cell-wall biosynthesis. Specifically, vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls. The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Normally this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents the incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix. In addition, vancomycin alters bacterial-cell-membrane permeability and RNA synthesis. There is no cross-resistance between vancomycin and other antibiotics. Vancomycin is not active in vitro against gram-negative bacilli, mycobacteria, or fungi.

DOSAGE

INDICATIONS DOSAGE
Endocardits2g IV divided either as 500mg every 6 hours or 1g every 12n hours *
Staphylococcal Infections

Endocardits

  • Staphylococcal Endocarditis
  • Streptococcus viridans or S.bovis (Effective alone or in combination with aminologycoside)
  • Diptheroid Endocarditis (Combination with either rifampicin, an aminoglycoside)

Staphylococcal Infections

Including septicemia, Bone Infections, Lower Respiratory Tract Infections, Skin & Skin Structure Infections. When staphylococcal Infections are localized and purulent, antibiotics are used as adjuncts to appropriate surgical measures

* Administer at rate of no faster than 10mg/min, or over atleast 60 minutes, whichever is longer.

** Duration of therapy 7-10 Days